Job Description
Company Description
Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.
About the Role: The Bioinformatics Scientist II will join an interdisciplinary team working with an unprecedented set of clinical DNA whole genome and exome sequence data and multiple epigenetic data types produced by novel R&D pipelines at Guardant Health. The scope of this project provides unique opportunities for developing and learning novel analytical methods for DNA sequencing data, including cell free DNA-based genomic and methylation data integrated with epigenetic data sets.
Essential Duties and Responsibilities: - Work with large, complex data sets. Tend to non-routine analysis problems, applying deep epigenetic knowledge to conduct end-to-end analysis of epigenetic cell-free nucleic acid NGS data.
- Development, continuous improvement, and validations of biomarkers for Guardant Health oncology products.
- Develop or apply statistical methods and procedures to evaluate and validate Guardant Health technologies.
- Work with the Technology Development team to develop and analyze verification and validation experiments as part of regulatory submissions.
- Provide analytic support on individual samples and research activities.
- Develop scripts for research and development activities, and leverage cutting edge AI methods to continuously improve efficiency.
- Communicate research results through presentations and project reports as well as scientific publications.
Qualifications - PhD in Bioinformatics, Statistics, Computational biology, Genomics, or related quantitative fields and a minimum of 2-5 years related experience; may include post-doctoral experience.
- Deep understanding of library preparation methods used to generate next-generation sequencing data, including whole-genome and methylation sequencing, targeted sequencing, and RNA-seq
- Demonstrated experience in developing methods for analysis of experimental data in genomics and next-generation sequencing, under the context of product development
- Strong knowledge of statistics and computational biology algorithms for genomic analysis (including statistical methods employed in analytical validation) and cancer genomics (alignment, variant calling, general multivariate statistical inference)
- Excellent communication and teamwork skills to foster a highly collaborative environment, working with both experimental and computational scientists
Must have:
- 2+ years of variant calling experience
Additional Information Hybrid Work Model: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients. The US base salary range for this full-time position is $120,280 to $165,410. The range does not include benefits, and if applicable, bonus, commission, or equity. The range displayed reflects the minimum and maximum target for new hire salaries across all US locations for the posted role with the exception of any locations specifically referenced below (if any).
For positions based in Palo Alto, CA or Redwood City, CA, the base salary range for this full-time position is $141,500 to $194,600. The range does not include benefits, and if applicable, bonus, commission, or equity.
Within the range, individual pay is determined by work location and additional factors, including, but not limited to, job-related skills, experience, and relevant education or training. If you are selected to move forward, the recruiting team will provide details specific to the factors above.
Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.
Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to [click to reveal email address]
[email protected] Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
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Job Tags
Full time, Work at office, Work from home,